- Technologies: Site-directed mutagenesis, gene targeting, and recent advances in in vivo gene transfer techniques used to dissect gene function within an organism and to analyze the regulation of their expression.
- Fundamental knowledge derived from various animal and plant genetic models and their applications in biomedical and agri-food sectors.
Content
Lectures
I. Animal genetic models A. Animal transgenesis -Additive transgenesis in mice and other livestock - Subtractive & substitutive transgenesis by homologous recombination -Modification of the genome by CRISPER -Applications and strategies (examples: regulation - function of genes in mammals, creation of model animals for biomedical studies, production of recombinant proteins by transgenic animals, etc.) B. Animal models of human pathologies
II. Other genetic models -Why other genetic models? - Genetic screens by mutagenesis in the Arabidopsis thaliana plant - Developmental genetics in Danio rerio and Drosophila melanogaster - Decipher the protein interaction networks in Saccharomyces cerevisiae
Tutorials Initiation to scientific analysis in the thematic: rigorous interpretation, critical analysis, mastery of thematic scientific vocabulary; presentation and animation of a scientific problem in front of peers
Additional Information
- Technologies: Site-directed mutagenesis, gene targeting, and recent advances in in vivo gene transfer techniques used to dissect gene function within an organism and to analyze the regulation of their expression.
- Fundamental knowledge derived from various animal and plant genetic models and their applications in biomedical and agri-food sectors.
