? Understand methodologies and molecular strategies for creating animal and plant genetic models.
? Explore applications and strategies for using genetic models in basic, biomedical, and agrifood research.
? Gain insight into site-directed mutagenesis, gene targeting, and recent in vivo gene transfer techniques as essential tools for studying gene function and expression control.
Content
Lectures: I. Animal Genetic Models ? Animal Transgenesis: o Additive transgenesis in mice and livestock. o Subtractive and substitutive transgenesis via homologous recombination. o Genome modification using CRISPR. o Applications and strategies (e.g., gene regulation and function in mammals, creation of biomedical model animals, production of recombinant proteins). ? Animal Models of Human Pathologies. II. Other Genetic Models ? Why use other genetic models? ? Genetic screens by mutagenesis in Arabidopsis thaliana. ? Developmental genetics in Danio rerio (zebrafish) and Drosophila melanogaster. ? Deciphering protein interaction networks in Saccharomyces cerevisiae. Tutorials: ? Scientific analysis within the thematic area: rigorous interpretation, critical analysis, mastery of specialized vocabulary; presentation and discussion of a scientific problem with peers.
Additional Information
? Understand methodologies and molecular strategies for creating animal and plant genetic models.
? Explore applications and strategies for using genetic models in basic, biomedical, and agrifood research.
? Gain insight into site-directed mutagenesis, gene targeting, and recent in vivo gene transfer techniques as essential tools for studying gene function and expression control.
