老虎机游戏
Lectures (18h):
This course addresses fundamental cellular mechanisms during development, such as cellular and tissue morphogenesis (2D, 3D, and 4D) and acquisition of cell identity (patterning). These aspects and their molecular actors will be studied at cellular, tissue, and organism levels. Special attention will be given to internal mechanisms (transcriptional machinery, clock, polarity/architecture, mechanical forces) and external factors (cell-to-cell communication, environmental factors, morphogen gradients, cell movements).
Theoretical concepts will be illustrated with examples from developmental biology (somite formation, cell migration) and recent methodologies and technologies used to decipher these processes. Developmental mechanisms will be explained using data from various animal models such as Drosophila, C. elegans, zebrafish, Xenopus, and mouse.
To illustrate certain concepts, the establishment of reproductive cells (primordial germ cell differentiation, gametogenesis) will be presented. Terminal differentiation of reproductive cells will also be discussed to link development and normal physiology, focusing on gamete recognition and fertilization in mammals.
Tutorials (12h):
? Publication analysis: acquisition of cell identity and patterning
? Publication analysis: cell and tissue polarity
? Publication analysis: 2D and 3D structure acquisition
? Publication analysis: collective cell migration
? Publication analysis: stem cells
? Publication analysis: lateral inhibition in cell specification and patterning
Informations complémentaires
? Cell interactions and patterning during development.
? Cellular and tissue morphogenesis during development.
? Germ cell differentiation and gametogenesis.
